COVID-19: Mofuta o tlase oa JN.1 o na le phetisetso e phahameng le bokhoni ba ho phonyoha ha 'mele oa ho itšireletsa mafung 

Spike Phetoho (S: L455S) ke phetoho e ikhethang ea mofuta o monyane oa JN.1 o ntlafatsang haholo matla a eona a ho qoba 'mele oa ho itšireletsa mafung, o e nolofalletsang ho qoba li-antibodies tsa Sehlopha sa 1. Boithuto bo tšehetsa tšebeliso ea liente tse nchafalitsoeng tsa COVID-19 tse nang le protheine ea spike ho sireletsa sechaba le ho feta.  

Ho kena ka matla Covid-19 linyeoe li 'nile tsa tlalehoa likarolong tse ngata tsa lefatše. E ncha sub-variant JN.1 (BA.2.86.1.1) e fetohileng ka potlako ho tloha ho BA.2.86 phapang haufinyane e 'nile ea baka matšoenyeho.  

JN.1 (BA.2.86.1.1) sub-variant e na le phetoho e eketsehileng ea spike (S: L455S) ha e bapisoa le selelekela sa eona sa BA.2.86. Ena ke phetoho e ikhethang ea JN.1 e ntlafatsang haholo bokhoni ba eona ba ho qoba 'mele oa ho itšireletsa mafung, e e nolofalletsang ho qoba li-antibodies tsa Sehlopha sa 1. JN.1 e boetse e na le liphetoho tse tharo ho liprotheine tseo e seng tsa S. Ka kakaretso, JN.1 e ekelitse phetiso le bokhoni ba ho phonyoha ha 'mele oa ho itšireletsa mafung^1,2.  

Liente tsa COVID-19 li tsamaile hole ho tloha seoa sa seoa 'me li nchafalitsoe mabapi le protheine ea spike ho tobana le liqholotso tse hlahisoang ke mefuta e sa tsoa hlaha.  

Phuputso ea morao tjena e fana ka maikutlo a hore ho na le monovalent e nchafalitsoeng ente ea mRNA (XBB.1.5 MV) e sebetsa hantle ho matlafatsang likokoana-hloko tsa serum-neutralization antibodies haholo khahlanong le mefuta-futa e mengata e kenyeletsang khahlanong le JN.1. Phuputso ena e ts'ehetsa tšebeliso ea liente tse nchafalitsoeng tsa COVID-19 tse nang le protheine ea spike ho sireletsa sechaba le ho feta³.  

Haeba mofuta o tlase oa JN.1 o hlahisa kotsi e eketsehileng ho bophelo bo botle ba sechaba ho latela mefuta e meng e ntseng e potoloha, CDC e re ha ho na bopaki.⁴.  

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References:  

1. Yang S., et al a 2023. Phetoho e potlakileng ea SARS-CoV-2 BA.2.86 ho JN.1 tlas'a khatello e matla ea 'mele ea ho itšireletsa mafung. Khatiso ea pele ea bioRxiv. E ngotsoe ka la 17 Pulungoana 2023. DOI: https://doi.org/10.1101/2023.11.13.566860  
2. Kaku Y., et al a 2023. Litšobotsi tsa likokoana-hloko tsa mofuta oa SARS-CoV-2 JN.1. Khatiso ea pele ea bioRxiv. E ngotsoe ka la 09 Tšitoe 2023. DOI: https://doi.org/10.1101/2023.12.08.570782  
3. Wang Q. et al a 2023. XBB.1.5 monovalent mRNA vaccine booster e hlahisa li-antibodies tse matla tse thibelang likokoana-hloko khahlanong le mefuta e sa tšoaneng ea SARS-CoV-2. Khatiso ea pele ea bioRxiv. E ngotsoe ka la 06 Tšitoe 2023. DOI: https://doi.org/10.1101/2023.11.26.568730  
4. Setsi sa Taolo ya Mafu. Ntlafatso ho SARS-CoV-2 Variant JN.1 E lateloa ke CDC. E fumaneha ho https://www.cdc.gov/respiratory-viruses/whats-new/SARS-CoV-2-variant-JN.1.html   

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