Interferon-β bakeng sa Phekolo ea COVID-19: Tsamaiso ea Subcutaneous e Sebetsa haholoanyane

Liphetho tse tsoang tekong ea phase2 li ts'ehetsa maikutlo a hore tsamaiso e tlase ea IFN- β bakeng sa kalafo ea COVID-19 e eketsa lebelo la ho fola le ho fokotsa lefu..

Boemo bo sa tloaelehang bo hlahisitsoeng ke seoa sa COVID-19 bo fane ka tumello ea ho lekola mekhoa e fapaneng e ka bang teng bakeng sa kalafo ea linyeoe tse matla tsa COVID-19. Ho ntse ho lekoa lithethefatsi tse 'maloa tse ncha 'me tse seng li ntse li le teng li ntse li sebelisoa hape. Corticosteroids li se li fumanoe li le molemo. Kalafo ea interferon e se e ntse e sebelisoa bakeng sa mafu a bakoang ke kokoana-hloko joaloka lefu la sebete. Na IFN e ka sebelisoa khahlano le SARS CoV-2 ho COVID-19?  

Litekong tsa pele ho nako, IFN e ipakile e sebetsa khahlano le SARS CoV le MERS likokoana-hloko. Ka Phupu 2020, tsamaiso ea Interferon-β ka nebulisation (e leng pulmonary inhalation) e ile ea tlalehoa e bonts'a litholoana tse ts'episang tsa ho alafa linyeoe tse matla tsa COVID-19 tse ipapisitseng le data e tsoang tekong ea kliniki ea mohato oa 2. ^1,2.  

Joale, tlaleho ea morao-rao e ipapisitseng le tlhaiso-leseling e tsoang tekong ea kliniki ea mohato oa 2 e entsoeng ho bakuli ba 112 ba nang le COVID-19 sepetlele Pitié-Salpêtrière Paris, Fora e fana ka maikutlo a hore tsamaiso ea IFN- β ka tsela e tlase e ntlafatsa sekhahla sa ho fola le ho fokotsa lefu ho COVID-19. linyeoe ³.   

Li-interferon (IFN) ke liprotheine tse patiloeng ke lisele tse amohelang ho arabela tšoaetso ea kokoana-hloko ho bontša lisele tse ling bakeng sa boteng ba kokoana-hloko. Karabelo e fetelletseng ea ts'oaetso ho ba bang ba bakuli ba COVID-19 e fumanoa e amana le karabelo e sa sebetseng ea IFN-1 le blockade. IFN-β sephiri. E sebelisoa ho China ho phekola pneumonia ea vaerase ka lebaka la SARS CoV leha ho le joalo ts'ebeliso ea eona ha e ea lekana ⁴.  

Teko ea tleliniki ea mohato oa 3 bakeng sa tšebeliso ea Interferon (IFN) kalafong ea bakuli ba matla ba COVID-19 e ntse e tsoela pele. Tumello e tla itšetleha ka hore na liphetho tsa ho qetela li ka har'a moeli o amohelehang o boletsoeng ke balaoli.   

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mehloling   

1. NHS 2020. Litaba- Sethethefatsi se hemang se thibela bakuli ba COVID-19 ho mpefala le ho feta tekong ea Southampton. E ngotsoe ka la 20 Phupu 2020. E fumaneha inthaneteng ho https://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/News-and-updates/Articles/Inhaled-drug-prevents-COVID-19-patients-getting-worse-in-Southampton-trial.aspx E fihletsoe ka la 12 Hlakola 2021.  

2. Monk PD., Marsden RJ., Tear VJ., et al., 2020. Tšireletseho le katleho ea inhaled nebulised interferon beta-1a (SNG001) bakeng sa phekolo ea tšoaetso ea SARS-CoV-2: e sa tloaelehang, e foufetseng habeli, placebo- laoloa, mohato oa 2 teko. The Lancet Respiratory Medicine, E Fumaneha Inthaneteng 12 November 2020. DOI: https://doi.org/10.1016/S2213-2600(20)30511-7 

3. Dorgham K., Neumann AU., et al 2021. Ho nahanoa ka phekolo ea motho ka mong ea Interferon-β bakeng sa COVID-19. Li-antimicrobial Agents Chemotherapy. E ngotsoe Marang-rang 8 Hlakola 2021. DOI: https://doi.org/10.1128/AAC.00065-21  

4. Mary A., Hénaut L., Macq PY., et al 2020. Lebaka la Phekolo ea COVID-19 ka Nebulised Interferon-β-1b–Literature Review and Personal Preliminary Experience. Frontiers in Pharmacology., 30 Pulungoana 2020. DOI:https://doi.org/10.3389/fphar.2020.592543.  

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