Liteko tsa lisele tsa litoeba li bonts'a mokhoa o mocha o supang melemo e ka bang teng ea oli ea kokonate taolong Lefu la Alzheimer
Lefu la Alzheimer ke motho ea tsoelang pele boko lefu le amang batho ba limilione tse 50 lefatšeng ka bophara. Ha ho na pheko e fumanoeng hajoale Alzheimer's; mefuta e meng ea phekolo e fumanehang e ka imolla feela matšoao a amanang le lefu lena. Alzheimer's Boloetse bo khetholloa ka ho bokellana ha letlapa le thata, le sa qhibiliheng (la liprotheine tsa beta tsa amyloid) lipakeng tsa methapo ea kutlo. boko. Sena se lebisa ho fetisoeng ha matla ha maikutlo ho pholletsa le methapo ea kutlo le ho baka matšoao a Alzheimer's lefu - haholo-holo ho senyeha ha mohopolo. Liprotheine tsa Amyloid beta 40 le Amyloid beta 42 li teng ka bongata. lipoleiti. Amyloid beta liprotheine li ipapisitse le polelo ea protheine ea amyloid precursor (APP). Lipatlisiso li thehile bohlokoa ba protheine ea amyloid precursor ho Alzheimer's maloetse. Phokotso e itseng ea ts'ebetso ea APP e bonoa e le kalafo bakeng sa Alzheimer's, leha mokhoa o hlakileng o hlalosang pokello ea liprotheine tsa amyloid beta o so utloisisoe ka botlalo.
Liphuputso tse ngata nakong e fetileng li bontšitse hore moroetsana oli ea kokonate mohlomong e ama litsela tse 'maloa tseo ka nako eo li tlatsetsang tsoelopeleng ea Alzheimer's lefu. Oli ea coconut e na le li-acid tse mafura tse monyehang habonolo tse entsoeng ke sebete. Li-acid tsena tse mafura li ka boela tsa fetoloa ho li-ketone - tse nkoang e le mohloli o mong oa matla bakeng sa methapo ea kutlo. Oli ea kokonate e bontšitsoe hore e na le liphello tse khahlanong le oxidant ho sireletsa li-neurone. Lintho tsena li etsa hore oli ea kokonate e be mafura a khethehileng a lijo.
Phuputsong ea morao-rao e hatisitsoeng ka boko Research, bafuputsi ba batlisisitse liphello tse ka bang teng tsa oli ea kokonate polelong ea protheine ea bohlokoa ea amyloid precursor (APP) e ikarabellang bakeng sa ho thehoa ha letlapa la amyloid. Bafuputsi ba ile ba hlahloba polelo ea protheine ea pele ea amyloid le secretion ea li-peptide tsa amyloid ka liseleng tsa mammalian Neuro 2A (kapa N2a) lisele tse tse hlalosang mofuta oa APP. Mohala ona oa neural cell o sebelisoa ka tloaelo ho ithuta phapang ea neuronal, kholo ea axonal le litsela tsa matšoao. Phuputsong ea morao-rao, lisele tsa N2a li ile tsa phekoloa ka karolo ea 0-5 lekholong ea oli ea kokonate 'me sena se ile sa lebisa ho fokotseng polelo ea protheine ea amyloid ka liseleng le ho fokotsa secretion ea amyloid peptide 40 le 42. Ho phaella moo, oli ea kokonate e ile ea boela ea khothalletsa N2a. lisele tse phapang e bontšang hore oli ea kokonate e na le phello e sireletsang ho nts'etsopele ea lisele tsa neuronal.
Liphetho li bontšitse hore ADP-Ribosylation Factor 1 (ARF1) - a protheine ea bohlokoa bakeng sa tsela ea sephiri - e ka 'na eaba e tlatsetsa liphellong tsa oli ea kokonate ka bobeli ba pontšo ea APP le secretion ea amyloid peptide. Ho ne ho hlakile hore oli ea kokonate e fihletse sena ka ho sebelisana le ARF1. ARF1 e tsejoa e le boikarabelo ba ho hlophisa le ho tsamaisa liprotheine tsa seaparo ka seleng. Lena ke lekhetlo la pele kamano pakeng tsa ARF1 le ts'ebetso ea amyloid precursor protein (APP) e bontšoa. Mokhatlo ona o laoloa ka phekolo ea oli ea kokonate. Ho kokota ARF1 ho fokolitse secretion ea li-peptide tsa amyloid ho theha karolo ea protheine ea ARF1 taolong ea APP.
Phuputso e hlalosa karolo e neng e sa tlalehoa pele ea oli ea kokonate ho fokotsa polelo ea amyloid precursor protein (APP) le secretion ea li-peptide tsa amyloid, phello e finyelitsoeng ka lebaka la ho theoha-taolo ea ARF1. Kahoo, ARF1 e ikarabella bakeng sa lipalangoang tsa APP ka hare ho li-neurons ha oli ea kokonate e ama ts'ebetso le polelo ea APP. Boithuto bona bo fana ka lintlha tse ncha mabapi le khoebo ea intracellular ea amyloid precursor protein mme sena se bohlokoa ho utloisisa lefu la Alzheimer's.
Phuputso ena e fana ka maikutlo a hore ho sebelisa oli ea kokonate lijong tsa pele tsa bophelo ba motho, haholo-holo ho batho ba nang le liphatsa tsa lefutso. Alzheimer's lefu le bakoang ke histori ea lelapa, le ka lieha kapa la emisa ho qala ha lefu lena. Lithuto tsa morao-rao le tsa nakong e fetileng li fana ka lipatlisiso tse eketsehileng le liteko tsa kliniki ea batho ho lekola litekanyetso le polokeho ea oli ea kokonate. Oli ea kokonate ha e theko e tlaase, e fumaneha habonolo 'me e ka kenngoa habonolo lijong tsa bakuli ba kotsing.
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Mohloli (s)
Bansal A et al 2019. Oli ea kokonate e fokotsa polelo ea protheine ea amyloid precursor (APP) le secretion ea li-peptide tsa amyloid ka ho thibela ADP-ribosylation factor 1 (ARF1). Patlisiso ea Boko. https://doi.org/10.1016/j.brainres.2018.10.001
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