Ho hanyetsa lithibela-mafu haholo-holo ka baktheria ea Gram-negative e batlile e baka mathata a kang boemo. Pale ea lithibela-mafu Zosurabalpin (RG6006) e bontša litšepiso. E fumanoe e sebetsa khahlano le libaktheria tse hananang le lithethefatsi, Gram-negative CRAB lithutong tsa pele ho tleliniki.
Antimicrobial resistance (AMR), e susumetsoang haholo ke tšebeliso e mpe le tšebeliso e feteletseng ea meriana e thibelang likokoana-hloko, ke e 'ngoe ea likotsi tse ka sehloohong tsa bophelo bo botle ba sechaba.
Tšoaetso ea baktheria ea gram-negative e ameha haholo. Ha ho bonolo ho boholo ba lithibela-mafu ho tšela lera ka hare le ka ntle le teng sehlopheng sena sa libaktheria ho kena liseleng tsa baktheria ho bontša liketso tsa bactericidal. Hape, libaktheria tsa Gram-negative li bokelletse tekanyo e phahameng ka ho fetesisa lithibela-mafu hanyetsa.
Acinetobacter baumannii ke baktheria ea Gram-negative. Ho tšoaetsoa ke e 'ngoe ea mefuta ea eona e bitsoang 'carbapenem-resistant Acinetobacter baumannii' (CRAB) ho thata ho phekola ho sebelisoa lithibela-mafu. Ho na le tlhokahalo e potlakileng ea ho sebetsa ka katleho lithibela-mafu khahlano le CARB kaha sekhahla sa batho ba shoang se phahame (hoo e ka bang 40% -60%) se neng se bakoa haholo ke khaello ea ts'ebetso e sebetsang. lithibela-mafu. Khatelo-pele e lebisang sepheong sena e tlalehiloe.
Bo-rasaense ba khethile sehlopha sa libuka tsa lithibela-mafu e leng, tethered macrocyclic peptides (MCPs) tse sebetsang kgahlanong le baktheria ya Gram –ve A. baumannii ho kenyeletswa CARB ka ho thibela ho tsamaiswa ha baktheria lipopolysaccharide ho tloha lera le ka hare ho ya lera le ka ntle.
Zosurabalpin (RG6006) ke lithibela-mafu mokhethoa oa sehlopha sa 'tethered macrocyclic peptides (MCPs)'. Pele hokliniki Liteko tse kenyelletsang lithuto tsa in vitro le lithuto tsa in vivo ka mefuta ea liphoofolo, Zosurabalpin e fumanoe e sebetsa khahlano le li-isolates tse hanyetsanang le lithethefatsi tsa 'carbapenem-resistant Acinetobacter baumannii' (CRAB) e tsoang libakeng tse fapaneng. E ile ea hlola ka katleho lithibela-mafu-mokhoa oa ho hanyetsa oa tlhahiso ea CARB Zosurabalpin e na le bokhoni.
Ka hona, motho kliniki liteko li se li qalile ho hlahloba polokeho le katleho Zosurabalpin ho phekola mafu a hlaselang a bakoang ke CRAB.
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References:
- Zampaloni, C., Mattei, P., Bleicher, K. et al. Pale lithibela-mafu sehlopha se shebileng sepalangoang sa lipopolysaccharide. Tlhaho (2024). https://doi.org/10.1038/s41586-023-06873-0
- Hawser S., et al a 2023. Ketsahalo ea Novel Antibiotic Zosurabalpin (RG6006) khahlano le Kliniki Acinetobacter Isolates ho tloha China, Open Forum Infectious Diseases, Volume 10, Issue Supplement_2, December 2023, ofad500.1754, https://doi.org/10.1093/ofid/ofad500.1754
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