Ka lekhetlo la pele bo-rasaense ba thehile hydrogel e nang le ente eo pele e kenyelletsang limolek'hule tse ikhethileng tsa bioactive ka li-crosslinkers tse ncha. Hydrogel e hlalositsoeng e na le bokhoni bo matla ba ho sebelisoa boenjiniere ba lisele
Matheka boenjiniere ke nts'etsopele ea li-tissue le li-substitutes tsa setho - li-cellular tse nang le likarolo tse tharo - tse nang le thepa e tšoanang le ea tlhaho. Ho etsa boenjiniere ba lithane e ikemiselitse ho khutlisetsa, ho boloka kapa ho matlafatsa tšebetso ea lisele ka ho sebelisa li-scaffolds tsena tse sebetsang ka bioloji. Synthetic gel ea hydrogel Li-polymer li 'nile tsa thoholetsoa e le batho ba tšepisang ho fana ka li-scaffolds tse joalo ka lebaka la sebopeho sa tsona se ikhethang le ho tšoana ha tsona le matrix a extracellular a tlhaho. Li-Hydrogels li etsisa tikoloho ea lisele, 'me li-crosslink ka har'a li-hydrogel li thusa thepa ho boloka sebopeho sa eona le ha e montse metsi a mangata. Leha ho le joalo, li-hydrogel tse teng hona joale li na le bioloji 'me ka hona li ke ke tsa sebetsa ka botsona ho tsamaisa tšebetso e nepahetseng ea tlhaho. Li hloka tlatsetso ea li-biomolecules tse tsamaellanang (mohlala, lintlha tsa kholo, li-ligands tse khomarelang) ho li etsa karolo ea bohlokoa ea li-hydrogel.
Phuputsong e hatisitsoeng ka June 11 ka Tsoelo-pele ea Saense, bo-rasaense ba thehile modular injectable hydrogel e ncha e sebelisang crosslinker e bitsoang PdBT - motsoako oa biodegradable - bakeng sa crosslinking ea hydrogel polymer ho etsa hydrogel e ruruhileng, e nang le bioactive. PdBT e kenyelletsa limolek'hule tsa bioactive ka ho li kenya ka har'a lik'hemik'hale tsa lik'hemik'hale tsa hydrogel. Li-biomolecules tse khethehileng li ka kopanngoa feela le PdBT mocheso oa kamore 'me ka ho etsa joalo limolek'hule tsa bioactive li fetoha karolo e kopantsoeng ea hydrogel. Sistimi e joalo, e ntlafalitsoeng ka lekhetlo la pele, e na le bokhoni ba ho tlama li-biomolecules tse ikhethileng ka har'a mocheso oa kamore hore li sebetse ntle le ho hloka ente ea bobeli kapa sistimi hamorao.
Li-biomolecules tse ekelitsoeng li lula li tsitsitse ho hydrogel 'me li ka hlahisoa ka ho toba ho lisele tse lebisitsoeng. Sena se thibela ho hasana sebakeng se kantle ho sebaka seo ho shebiloeng ho sona ho qoba litlamorao tse sa batleheng joalo ka ho se sebetse kapa ho hola ha lisele tse ngata. Liteko li ile tsa etsoa ka masapo le lefufuru ka ho sebelisa li-monomers tse khethehileng tsa PdBT ka ho eketsa ts'ebetso ka ho kenyelletsa lefufuru le amanang le hydrophobic N-cadherin peptide le hydrophilic bone morphogenetic protein peptide, le glycosaminoglycan e entsoeng ka lefufuru, chondroitin sulfate. Motsoako ona oa hydrogel o ka kenngoa ka ho toba ka har'a lisele tse lebisitsoeng. Li-biomolecules tse kenyellelitsoeng ka har'a hydrogel li kopana le lisele tsa 'mele tsa mesenchymal tsa lisele tse amohelang le ho li "hoka" hore li eketsoe sebakeng seo ho lebeletsoeng ho sona ho 'peo' kapa ho qala kholo e ncha. Hang ha lisele tse ncha li ntse li hōla, hydrogel e theola 'me ea nyamela.
Hydrogel e ncha e hlalositsoeng thutong ea hajoale e ka lokisoa ka mocheso oa kamore hore e sebelisoe hanghang 'me e ka etsoa ka mokhoa o nepahetseng bakeng sa lisele tse fapaneng. Ts'ebetso e otlolohileng ea ho itokisa e thibela ho senyeha ha mocheso oa li-biomolecule e 'nileng ea e-ba bothata ka li-hydrogel tse fetileng kaha sena se ama ts'ebetso ea bona ea tlhaho. Li-hydrogel tsa bioactive li ka thusa ho nchafatsa masapo, lefufuru, letlalo le lisele tse ling. Mokhoa ona o mocha o sebelisang ente ea bioactive hydrogel e nang le thepa e ntle e na le monyetla o matla oa ho sebelisoa boenjiniere ba lisele.
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{U ka bala pampiri ea mantlha ea lipatlisiso ka ho tobetsa sehokelo sa DOI se fanoeng ka tlase lethathamong la (ma) mehloli e boletsoeng}
Mohloli (s)
Guo JL le ba bang. 2019. Modular, tishu-specific, le biodegradable hydrogel cross-linkers bakeng sa boenjiniere ba lisele. Tsoelo-pele ea Saense. 5 (6). https://doi.org/10.1126/sciadv.aaw7396
